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广西11选5 > 技术支持 > 简析冻干技术在生物制药领域的应用

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简析冻干技术在生物制药领域的应用
发布时间:2017-09-14   点击次数:2803次

广西11选5     SHENGWUJISHUZAIERSHIYISHIJIDEKEXUEJISHUFAZHANZHONGZHANYOUZHONGYAODIWEI,SHENGWUJISHULINGYUYECHENGWEILEDANGJINGAOXINJISHUZHONGFAZHANzuiWEIXUNMENGDELINGYU,GEGEGUOJIAKEXUEJISHUFAZHANZHONGSUOBIXUQIANGZHANDEZHIGAODIAN。LENGDONGGANZAOJIZAISHENGWUZHIYAOFANGMIANYINGYONG,KEYIDADAJIEJUESHENGHUAYAOWUHESHENGWUZHIJIDEHUAXUE、WULI、SHENGWUDEBUWENDINGXINGWENTI。YINWEIXIAOBINGJINGTIDESHENGHUA,GUTIWUZHIZAIDONGGANHOUWANGWANGYIDUOKONGJIEGOUBAOCHIDONGJIEQIANDETIJI,ERJIASHUIHOUYIRONGJIEFUYUAN,GAIPINZHIDEWUZHIZAISHENGHUAGUOCHENGZHONGXUYAOMANZUYIDINGDETIAOJIAN。CONGSHENGWUYAOZHIPINDEWENDUKAN,YIBANNENGGOUBAOCHIDIYU-25℃DEDIWENZHUANGTAI,JIAOSHIYIGANZAOMEI、JISU、HESUAN、XUEYEHEMIANYIZHIPINDENGBUNAIREDEWUZHI。SHENGWUYAOZHIPINGANZAOHOUNENGGOU JIANG95%~99%YISHANGDESHUIFENPAICHUCHUQU,QIEGANZAOGUOCHENGXUYAOZAIZHENKONGTIAOJIANXIAJINXING,ZHEIYANGQUDEDEZHIPINCAIBUYIBEIYANGHUA,GUGAIJISHUSHIYUZHANGQIBAOCUNZHIPIN。SUIZHESHENGWUZHIYAODEXUNMENGFAZHAN,DONGGANJISHUYIJINGBEIYAOYESHENGCHANSHIJIANZHENGSHIWEISHIYIZHONGSHIFENYOUXIAODEJISHU,BINGJIANGZAIZHIYAOYECHIXUFAZHANDEGUOCHENGZHONGYUJIAXIANSHICHUQIYOUYUEXING。

一、冻干技术简介
  真空冷冻干燥技术简称冻干,是一种集真空、制冷、干燥等多种技术为一体的高新干燥技术。不仅如此,冻干技术还涉及传热传质、流体力学、自动控制、食品营养、生物工程、材料学等多学科领域的专业知识。冻干技术因在真空低温状态下实现制品的脱水干燥,而成为医学生物制品的干燥保存方法。冻干技术在二十世纪初经沙克尔对生物制品采取冻干保存效果良好之后,获得了各国学者的广泛关注。

  ERSHISHIJISISHINIANDAIZAIWEI*BAOCUNQINGMEISUYUXUEJIANGZHIHOU,YUSHANGYESHENGCHANZHONGDEDAOLEYINGYONG,YONGYUDONGGANJUNZHONG、PEIYANGJI、HEERMENG、WEISHENGSU、RENXUEJIANGJIYAOPINDENGYIYAOZHIPINDEGANZAOBAOCUN。ERSHISHIJIZHONGQI,YOUYUGELEIXINGLENGDONGGANZAOSHEBEIDEBUDUANWENSHI,DONGGANJISHUDEYIBUDUANTIGAO。DIANZIJISHUDEXUNMENGFAZHANTIGONGLEDUOWEIDEJISHUXINXIHESHOUDUAN,CUJINLEZHENKONGDONGGANSHEBEIZIKONGXITONGDEZHUBUWANSHAN,GANZAOGUOCHENGJIEZHUYUWEIJISHIXIANLEQUANZIDONGKONGZHI,BINGCHANSHENGLETIGONGDUOTAISHEBEIJIDUOZHONGGANZAOGONGYIGONGZIZHUXUANZEDEQUNKONGKONGZHIFANGSHI。WOGUODEDONGGANJISHUZHUYAOSHIZAIERSHISHIJIBASHINIANDAIHOUSHIYINGSHICHANGXUQIUERFAZHANQILAIDE,SHEBEIXINGNENGHECHANPINZHILIANGJIANCIDADAOGUOJISHUIPING,QIYINGYONGFANWEIYECONGDANCHUNDEYIXUESHENGWUZHIPINZHUJIANKUOZHANDAOSHIPIN、CAILIAO、HANGKONGDENGDUOGEFANGMIAN。

 

广西11选5  DONGGANJISHUKEYIYONGLAIGANZAOREMINXINGWULIAOHEXUYAOBAOCHISHENGWUHUOXINGDEWUZHI。QIGUOCHENGYIBANSHIXIANZAIDIWENHUANJINGXIALENGDONGBEIGANZAOYAOYESHIQISUOHANSHUIFENNINGJIE,RANHOUZAIZHENKONGHUANJINGXIARANGWULIAODEGUTAISHUIFENSHENGHUA,SHIQIDEYIGANZAO。DONGGANJISHUBUJINKEYIzuiDAXIANDUDIFANGZHIGANZAOGUOCHENGZHONGWULIAODELIHUAHESHENGWUXUEBIANXING,JIANSHAODUISHENGWUZUZHIHEXIBAOTIZAOCHENGDESUNHAIHEHUOJUNTIJIBINGDUDESIWANG。DONGGANFANGFADESHIYONGKEYINONGSUOYETIYAOWU,ERBUGAIBIANYANSE,QIEZHUANGTAISHUSONG,ZAIJIASHUIHOUKEYIJIKERONGJIE,BUJINWENDINGXINGLIANGHAO,ERQIEJIANSHAOLESHOUWURANDEJIHUI,YINERYUNSHUFANGBIAN,KEYIBAOCUNGENGZHANGSHIJIAN,YAOWUDEZHILIANGYEDEDAOLETISHENG。

  RURENXUEJIANGJINGDONGGANHOU,QIBAOCUNQIXIANKECONGZHIQIANDEJIGEYUEYANZHANGZHI5~10 NIAN;MAZHENRUODUHUOYIMIAOJINGDONGGANHOU,QIBAOCUNQIXIANYEKECONGZHIQIANDE 3 GEYUEYANZHANGZHI 1 NIAN。DONGGANDEQUEDIANSHITOUZI、WEIHUJICHANPINCHENGBENGAO。XIANZAIWOGUOHENDUOZHIYAOQIYEDOUSHIYONGDONGGANJISHULAIJIAGONGSHENGWUYAOPIN,RUKANGJUNSU、YIMIAO、MEIZHIJI、XUEJIANGDENG。

二、冷冻干燥机的性能指标
  冷冻干燥机性能值得认真分析。冷冻干燥机的应用除需具备zui为先进的冻干技术外,还应当具备安全性、可靠性、适用性和经济性的性能指标。

广西11选5      *,LENGDONGGANZAOJIDEXINGNENGZHIBIAOBAOKUOGEBANMIANJI、GEBANJIANJU、LENGNINGQIBUSHUILIANGDENGZAINEIDEYIXIEGUIGEHERONGLIANGJUNYINGDANGHELENGDONGGANZAOJIDESHENGCHANLIANGHUXIANGPIPEI;

     DIER,LENGDONGGANZAOJIGEBANYAOPINGZHENG、WENDUYAOJUNYUN,DIANWENCHAJUNYINGXIANZHIZAI±1℃NEI,YIZHEIYANGDETIAOJIANLAIBAOZHANGSUOSHENGCHANCHULAIDETONGYIPICIDECHANDEPINZHILIANGJUNYUNYIZHI;

     DISAN,SHUIQININGJIEQIYINGDANGNENGGOUZAI 2~5h ZHINEIJIANGWENDUJIANGZHISUOXUSHUIPING,TONGCHANGWEIDIYU 45℃;

     DISI,DUIKONGXIANGXIANGTIZHENKONGDUJINXINGCEDING,YINGDANGZAI 30minNEIDADAO 2.66 Pa.YINLENGDONGGANZAOJIDEXIANGTI、BANCENGHELENGNINGQIDOUXUYAOCHENGSHOUXIANGYINGDENEIWAIBUYALI,YIDANQIZAIZHENKONGHUANJINGXIAFASHENGXIELOU,BIANHUIZAOCHENGYAOPINDEWURAN。SUOYI,BIXUDUILENGDONGGANZAOJINEIWAIYABUJIANJINXINGYANGEDEZHENKONGCESHI,SHIZHIFUHEJUTIDEZHIBIAOGUIDING;

     DIWU,DONGGANXIANGTIYIBANCAIYONGDAYUANJIAOJIEGOU,LENGDONGGANZAOJIXIANGTICAIZHIYINGDANGCAIYONGNAIFUXINGJIAOGAODEBUXIUGANG,QIESHEJIYINGDANGHELI、BIANYUQINGXI,.SUOYOUYUYAOPINZHIJIEHUOJIANJIEJIECHUDEXIANGTI、BANCENG、RUANGUAN、LENGNINGQI、FAMENDENGBUJIANJUNYINGDANGCAIYONGKANGFUSHIXINGLIANGHAODEDITANBUXIUGANGCAIZHI。XIANGTI、BANCENGHELENGNINGQIDENGBUJIANWEIBIANYUQINGXI,QINEIBUJIEGOUSHEJIYINGDANGJINLIANGJIANDAN,BUNENGCUNZAIBUYIQINGXIDESIJIAOJIEGOU。QINGJIESHI,BIXUSHIYONG 50~65℃DECHAOLVSHUI,QIEBUNENGZHONGFUSHIYONG。LENGDONGGANZAOJIDELINGBUJIANYAORONGYICHAIZHUANGYIFANGBIANWEIXIUHULI。LENGDONGGANZAOJIXIANGTIHEBANCENGDEBIAOMIANYAOJINGGUOJINGMIANPAOGUANGCHULI,YIDADAOJIANXIAOZHENKONGFANGQILIANGHEYIYUQINGJIEDEMUDE。

三、冻干过程
  真空冷冻干燥的全过程包括预冻、升华干燥和解析干燥三个阶段。各阶段都有各阶段的要求,不同物料的要求也不尽相同。冻干产品的质量与制品的浓度,罐装的厚度,容器的形状、容量、口径及热导性,各阶段的工艺设计及控制手段均直接相关。

广西11选5        *,YUDONGJIEDUAN。YUDONGYAOXIANJIANGWULIAODONGJIE,XUNSUSHIQIWENDUDIYUGONGJINGDIAN(GONGJINGDIANJISHIWULIAOZHONGSUOHANDEBUTONGCHENGFENGONGTONGDONGJIESHIDEWENDU),WEISHENGHUAJIEDUANDAXIAXIANQIJICHU。YUDONGJIEDUANZHUYAOYIDONGJIEWENDUGAODIHEDONGJIESUDUWEIKONGZHIMUDE。WENDUYAOJIANGDAODIYUWULIAODONGJIEDIAN,ERDONGJIEDIANYINWULIAODEBUTONGERGEYI。DONGJIESUDUZHIJIESHIWULIAODEBINGJINGKELIDAXIAOSHOUDAOYINGXIANG,ERGUTAIWULIAODEJIEGOUHESHENGHUASUDUYOUQUJUEYUBINGJINGKELIDEDAXIAO。TONGCHANGYAOQIUWULIAODONGJIEZAI 1~3hNEIWANCHENG,RANHOUJINRUSHENGHUAGANZAOJIEDUAN;

广西11选5        DIER,SHENGHUAGANZAOJIEDUAN。DONGGANDEZHUYAOGUOCHENGJIUSHISHENGHUAGANZAO。SHENGHUAGANZAODEMUDEJIUSHISHIWULIAOZHONGDEBINGSHENGHUACHULAI。SHENGHUAGUOCHENGZHONGBUYUNXUBINGRONGHUA,YIDANFASHENGBINGRONGHUADEQINGKUANG,ZEZHENGGEDONGGANGUOCHENGJIUXUANGAOSHIBAI。SHENGHUABIXUBAOZHENGBINGBURONGHUAHEBINGZHOUWEISHUIZHENGQIDIYUWULIAODONGJIEDIANBAOHEZHENGQIYAZHEILIANGGEJIBENTIAOJIAN。SHENGHUAGANZAOJIEDUANJIYAOSHISHUIZHENGQIBUDUANYIZOU,BAOZHENGSHUIZHENGQIYADIYUBAOHEZHENGQIYA,YOUYAOSHIGANZAOSUDUDEDAOTISHENG,BAOZHENGBUJIANDUANDITIGONGWEICHISHENGHUAGUOCHENGSUOXUDEQUANBURELIANG,ZHEIJIUYAOQIUzuiYOUHUASHUIZHENGQIYAHEGONGREWENDUKONGZHI,SHISHENGHUAGANZAONENGGOUSHIXIANKUAISU、DINENGHAO。SHENGHUAGANZAOJIEDUANYINCHANPINDEBUTONGQISHIJIANZHANGDUANGEYI;

        DISAN,JIEXIGANZAOJIEDUAN。JINGSHENGHUAGANZAOHOU,WULIAOZHONGDESUOYOUBINGJINGJUNYICHU,ZHEIHUISHIWULIAONEIBUCUNLIUHENDUOKONGXUE,DANZAIWULIAODEJIZHINEIRENGJIANGCANLIU 10%ZUOYOUDEWEIDONGJIESHUIFEN,JIEXIGANZAOJIUSHIYAOJIANGDICANLIUWEIDONGJIESHUIFENDEZHILIANGFENSHU,SHIQIJIANGDAO 2%ZUOYOU,BINGzuiZHONGDEDAOWANQUANGANZAOHOUDEWULIAO。

四、总结
广西11选5  21 世纪的人类高科技发展将以生物、材料、电子、信息科学等领域的重大发展为标志,在生物制药过程中应用真空冷冻干燥技术必将为医学发展提供技术依托,为医治人类的病患 ,保障人的身体健康必将发挥更积极的作用。

 

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